منابع مشابه
Insulitis Revisited.
Restricted access to the inflammatory lesions in patients with type 1 diabetes (T1D) has slowed insight into human insulitis. The conception of a network collecting pancreases of donors with diabetes (Network for Pancreatic Organ Donors with Diabetes [nPOD]; www.jdrfnpod.org) has focused the international diabetes research community on islet inflammation in new tissue for the first time in deca...
متن کاملInsulitis in NOD Mice
The active form of vitamin D, 1,25(OH)2D3, can prevent various forms of experimentally induced autoimmune disorders. The aim of this study was to confirm these findings in NOD mice that spontaneously develop an autoimmune type of diabetes mellitus. Therefore, the effect of a long-term 1,25(OH)2D3 treatment on the incidence of insulitis, the histological lesion preceding diabetes, was studied. F...
متن کاملQUICKSELECT Revisited
We give an overview of the running time analysis of the random divide-and-conquer algorithm FIND or QUICKSELECT. The results concern moments, distribution of FIND’s running time, the limiting distribution, a stochastic bound and the key: a stochastic fixed point equation.
متن کاملPENDRED\'S SYNDROME REVISITED
Pendred's syndrome is defined as a triad of congenital perceptive hearing loss, goiter, and abnormal perchlorate test. Three brothers with Pendred's syndrome [P.S.] are reported. The oldest brother has hearing loss (he has been deaf and mute since childhood) and has a large goiter. A thyroid scan revealed euthyroid multinodular goiter and a perchlorate test was performed, and reported abno...
متن کاملA Humanized Mouse Model of Autoimmune Insulitis
Many mechanisms of and treatments for type 1 diabetes studied in the NOD mouse model have not been replicated in human disease models. Thus, the field of diabetes research remains hindered by the lack of an in vivo system in which to study the development and onset of autoimmune diabetes. To this end, we characterized a system using human CD4(+) T cells pulsed with autoantigen-derived peptides....
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ژورنال
عنوان ژورنال: Diabetes
سال: 2016
ISSN: 0012-1797,1939-327X
DOI: 10.2337/dbi15-0040